The FRAME Alternatives Laboratory has recently worked with the Arthritis Research UK Pain Centre to study biomarkers associated with symptomatic and asymptomatic osteoarthritis of the knee.
A selection of posters that show the current research projects taking place at the FRAME Alternatives Laboratory.
Undergraduate students from Nottingham Trent University have worked on behalf of FRAME with the aim of promoting engagement with the issues affecting animal experimentation and alternatives, and exploring ways in which it can be incorporated into the secondary school curriculum. The university students created a survey to identify what if anything is already taught, what […]
Between April 2014 and March 2015, 429 patients died waiting for an organ transplant in the UK. A further 807 patients were removed from the transplant list as deteriorating health meant that an organ donation would no longer be in the patient’s best interest. The lack of donated viable organs has led researchers to try […]
FRAME carried out a review of mouse models used to study Parkinson’s disease. The findings were presented by intern Michelle Maurer from Johannes Gutenberg University of Mainz, Germany. Download the slides by clicking here: Parkinsons_Mouse_Presentation Related Posts Current research projects at the FRAME Alternatives Laboratory A selection of posters that show the current research projects taking place […]
FRAME Scientific Director Dr Gerry Kenna gave a lecture at the Dr Hadwen Trust Animal Replacement Science Conference. His topic was Using non‐animal methods to predict and avoid human adverse drug reactions. Download the slides by clicking here: Adverse Drug Reactions. Related Posts First FRAME debate FRAME is holding its first ever debate tomorrow (April 23) […]
The FRAME Alternatives Lab is able to differentiate human mononuclear blood cells into human osteoclasts (bone eating cells). Osteoclast dysfunction has been observed in a variety of bone diseases including osteoarthritis. The lab is currently investigating potential therapeutic agents which will decrease osteoclast activity in arthritis and reduce bone and joint damage. Related Posts Human-based […]
Much of the research into obesity and diabetes is carried out using transgenic animal models. FRAME’s experience and that of many others is that such animal models are of little use when trying to study human diseases and responses to potential therapies. The FRAME Alternatives Laboratory cultures primary human adipocytes and skeletal muscle myotubes to […]
It is well known that lipids (fatty substances) can have a positive effect on skin. A new project at the FRAME laboratory will enable close investigation of how lipids are absorbed to create those effects. The project will involve building three-dimensional models from keratinocytes, fibroblasts, melanocytes and immune cells. They will be isolated directly from […]